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KMID : 0381219890210010060
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Journal of RIMSK
1989 Volume.21 No. 1 p.60 ~ p.72
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Effects of Vasodilators in Pulmonary Edema
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Abstract
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Vasodilators are commonly used to decrease after load and improved left ventricular function in patients with congestive heart failure, and despite a large fall in systemic vascular resistance, blood pressure remains relatively constant. Also certain vasodilators have been shown to be effective in decreasing pulmonary vascular resistance and increasing cardiac output in patient primary pulmonary artery pressure secondary to pulmonary edema.
We were studied the hemodynamic and blood gas changes of vasodilators (hydralazine and minoxidil) with continuous positive pressure ventilation in pulmonary edema. The results were as follows;
In pulmonary edema group, Arterial oxygenation was improved after applying 10 cm H2O PEEP, but cardiovascular system was depressed. Blood pressure and cardiac output were decreased. CVP, MPAP and PCWP were increased.
In hydralazine or minoxidil treated group, arterial oxygen and carbon dioxide were improved with lower degree PEEP 5 cm H2O.
In hydralazine treated group, blood pressure and cardiac output were decreased after applying 10 cm H2O and SaO2 were improved at 5 cm H2O, but blood pressure was decreased and heart rate was increased. SVR and PVR were not changed. Cardiac output was diminished at high degree PEEP 15 cm H2O.
So we were concluded that lower degree PEEP 5 cm H2O is more beneficial in vasodilator treated group.
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